OralDNA  Salivary Genetic Tests




Approximately 50% of the variability in the severity of clinical periodontal disease is due to genetic influences, such as Interleukin -1 (IL-1) gene cluster variants.  In patients presenting with a genetic risk for  an exaggerated immune response (which in turn translates into more tissue destruction), treatment modifications such as more frequent removal of the biofilm or host-modulating drugs such as low-dose doxycycline may be indicated (Friedewald 2009). 


Oral DNA Labs offers a number of salivary genetic tests that can provide valuable information about a patient's periodontal disease and systemic inflammatory risk. 


MyPerioPath provides semi-quantitative levels of 11 different species of bacteria known to trigger periodontal disease. In addition to identifying the bacterial pathogens, the test provides a bacterial-related risk of disease progression and suggestions for suitable antibiotic therapy. MyPerioPath may also be used to track the effectiveness of therapies like the PerioProtect method at a microbiological, not just clinical level. 

  



The MyPerioID test detects genetic changes (DNA polymorphisms) that have been associated with increased incidence and/or progression of chronic periodontal disease in some studies.

Celsus One is a new test that evaluates eight major markers for oral and systemic inflammation - from IL-1, which is associated with increased plaque formation and rupture, increased risk for diabetes and severe periodontal disease, to TLR4, which is associated with rheumatoid arthritis. 



This information can be used to develop patient-specific treatment plans for periodontal disease therapy and to help establish the therapy endpoint, as well as provide the patient's medical team with additional insights that might require modification of the patient's cardiopreventive program. 

In addition to these tests, OralDNA Labs offers OraRisk Candida (identifying the species responsible for oral yeast infections and providing treatment recommendations); and OraRiskHPV, which detects the presence of HPV virus strains associated with a higher risk of oral cancer development. 


Sources: 

Friedewald, Vincent E., et al. "The American Journal of Cardiology and Journal of Periodontology Editors' Consensus: Periodontitis and Atherosclerotic Cardiovascular Disease♦." Journal of periodontology 80.7 (2009): 1021-1032.

OralDNA Labs:  http://www.oraldna.com/